β-Blocker Overdose

Toxicology

Bradycardia, hypotension from β-adrenergic blockade.

Management

  • ABCDE, activated charcoal <1 h if awake
  • Atropine 500 mcg IV (often ineffective)
  • IV fluids
  • Glucagon 5-10 mg IV bolus then 2-5 mg/h
  • High-dose insulin (HDI): 1 U/kg bolus + 1-10 U/kg/h with dextrose
  • Vasopressor (adrenaline, noradrenaline)
  • Lipid emulsion 1.5 mL/kg 20% bolus if propranolol/lipophilic
  • ECMO if refractory

Related in WardRound

Educational — verify locally.

WardRound

WardRound

Clinical Decisions in Seconds