Atrial Fibrillation

Cardiology

Supraventricular tachyarrhythmia with uncoordinated atrial activation and irregular ventricular response.

Causes

  • HTN, HF, valvular disease
  • Thyroid disease, alcohol
  • Sepsis, PE, post-op
  • Lone AF

Clinical features

  • Palpitations, dyspnoea, chest pain, dizziness
  • Asymptomatic in 30%

Investigations

  • 12-lead ECG
  • TSH, U&E, TFT, LFT
  • Echo (structural)
  • Ambulatory monitoring if paroxysmal

Management

  • Rate control: β-blocker/CCB (target HR <110 lenient, <80 strict)
  • Rhythm control if symptomatic: DC cardioversion / flecainide (structurally normal) / amiodarone / ablation
  • Anticoagulation per CHA2DS2-VASc (≥2 M / ≥3 F)

Drug therapy

  • DOAC first-line (apixaban preferred in elderly/CKD)
  • LAA closure if OAC contraindicated
  • AAD: flecainide, sotalol, amiodarone

Complications

  • Stroke (5× ↑ risk)
  • HF, tachy-cardiomyopathy
  • Cognitive decline

Clinical pearls

  • ABC pathway: Anticoag, Better symptom control, Cardiovascular risk mgmt
  • Early rhythm control in HF (EAST-AFNET 4)

References

  • ESC 2020 AF Guidelines
  • AHA/ACC 2023 AF

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