Life-threatening organ dysfunction from dysregulated host response to infection (Sepsis-3).
Investigations
- • Blood cultures × 2 before antibiotics
- • Lactate, ABG, FBC, U&E, LFT, coag, CRP
- • Urinalysis + culture, imaging by source
Diagnosis
- • Suspected infection + qSOFA ≥2 or SOFA ↑ ≥2
- • Septic shock: sepsis + vasopressor need + lactate >2 despite fluids
Management
- • Hour-1 bundle: lactate, cultures, broad-spectrum antibiotics, 30 mL/kg crystalloid, vasopressors to MAP ≥65
- • Norad first line; add vasopressin 0.03 U/min if escalating
- • Hydrocortisone 200 mg/day in refractory shock
- • Source control ASAP
Complications
- • Multiorgan failure, ARDS, DIC, death
References
- • Surviving Sepsis Campaign 2021
Related in WardRound
Educational — verify locally.
