Digoxin Toxicity

Toxicology

See treatment and investigations.

Clinical features

  • Nausea, xanthopsia (yellow-green vision), confusion
  • Any arrhythmia — bidirectional VT classic

Investigations

  • Digoxin level (>2.6 ng/mL toxic; >6 severe)
  • K+ (hyperkalaemia in acute — prognostic marker)

Management

  • Digoxin-specific Fab fragments: life-threatening arrhythmia, K+ >5, level >12 ng/mL, ingestion >10 mg adult / 4 mg child
  • Correct Mg (Mg 2 g IV) and K (avoid calcium — controversial)
  • Atropine for bradycardia; pacing if refractory

Related in WardRound

Educational — verify locally.

WardRound

WardRound

Clinical Decisions in Seconds