Endocrinology · Long-acting GLP-1 receptor agonist
Semaglutide
Dose
0.25 mg SC weekly × 4 wk → 0.5 mg → 1.0 mg weekly (up to 2.4 mg for obesity). Oral: 3 → 7 → 14 mg OD fasting.
Use
T2DM with cardiovascular benefit; obesity management.
Monitoring
Weight, HbA1c, GI tolerance, retinopathy screening if rapid HbA1c drop.
Side effects
- • Nausea
- • Constipation/diarrhoea
- • Cholelithiasis
- • Delayed gastric emptying — anaesthetic risk
Related in WardRound
Always confirm dose against your local formulary / BNF before prescribing.
