Antibiotics · Extended-spectrum penicillin + β-lactamase inhibitor
Piperacillin-Tazobactam
Brand: Tazocin
Dose
4.5 g IV q8h (extend to q6h in severe sepsis)
Dose adjustment
CrCl <20: 4.5 g q12h
Use
Sepsis (broad), HAP, neutropenic sepsis, intra-abdominal, skin/soft tissue.
Monitoring
U&E, FBC, LFT.
Side effects
- • Diarrhoea
- • AKI (esp. with vancomycin)
- • Rash
- • Hypokalaemia
Related in WardRound
Sepsis
Protocol · Sepsis Six within 1 hour
Acute Cholangitis (Ascending)
Protocol · Charcot triad — Abx + biliary decompression
GI Perforation
Protocol · Resuscitate + broad Abx + surgery
Toxic Shock Syndrome
Protocol · Remove source + clindamycin + IVIG
Septic Abortion
Protocol · Antibiotics + evacuation
Sepsis & Septic Shock (ED)
Topic · Emergency Medicine
Neutropenic Sepsis
Topic · Oncology
Always confirm dose against your local formulary / BNF before prescribing.
