Piperacillin-Tazobactam

Antibiotics

Antibiotics · Extended-spectrum penicillin + β-lactamase inhibitor

Piperacillin-Tazobactam

Brand: Tazocin

Dose

4.5 g IV q8h (extend to q6h in severe sepsis)

Dose adjustment

CrCl <20: 4.5 g q12h

Use

Sepsis (broad), HAP, neutropenic sepsis, intra-abdominal, skin/soft tissue.

Monitoring

U&E, FBC, LFT.

Side effects

  • Diarrhoea
  • AKI (esp. with vancomycin)
  • Rash
  • Hypokalaemia

Always confirm dose against your local formulary / BNF before prescribing.

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