Antibiotics · 3rd-gen cephalosporin
Ceftriaxone
Dose
1–2 g IV/IM OD (meningitis 2 g BD)
Mechanism
Beta-lactam — inhibits PBPs, bactericidal
Indications
- • CAP, meningitis, pyelonephritis
- • Gonorrhoea, typhoid
- • SBP
Contraindications
- • Severe penicillin / cephalosporin allergy
- • Neonates with hyperbilirubinaemia (calcium-containing IV fluids)
Dose adjustment
No renal adjustment unless severe + hepatic impairment
Use
Broad gram-negative + good gram-positive cover; once-daily.
Monitoring
LFT, FBC if prolonged; biliary sludge.
Side effects
- • Rash, diarrhoea (incl. C. diff)
- • Biliary pseudolithiasis
- • Eosinophilia
Pregnancy safety
Safe
Related in WardRound
Viral Encephalitis
Protocol · Acyclovir empirically
Brain Abscess
Protocol · Antibiotics + drainage
Variceal Bleeding
Protocol · Terlipressin + ceftriaxone + endoscopy
Leptospirosis / Weil Disease
Protocol · Doxycycline / IV penicillin
Acute Chest Syndrome (Sickle)
Protocol · Transfuse + antibiotics
Acute Epiglottitis
Protocol · Airway + IV ceftriaxone
Enteric (Typhoid) Fever
Topic · Infectious Diseases
Leptospirosis
Topic · Infectious Diseases
Always confirm dose against your local formulary / BNF before prescribing.
