Plaque Psoriasis

Dermatology

Chronic immune-mediated inflammatory skin disorder with well-demarcated erythematous plaques and silvery scale.

Risk factors

  • FHx (HLA-Cw6)
  • Stress, smoking, alcohol
  • Streptococcal pharyngitis (guttate)

Clinical features

  • Itchy scaly plaques on extensors, scalp
  • Nail pitting, onycholysis
  • Joint pain (psoriatic arthritis)

Investigations

  • Clinical
  • Skin biopsy if atypical

Diagnosis

  • Auspitz sign, Koebner phenomenon

Differential diagnosis

  • Eczema
  • Lichen planus
  • Tinea corporis
  • Mycosis fungoides

Management

  • Emollients
  • Topical steroid + vitamin D analogue (calcipotriol)
  • Phototherapy (NB-UVB)
  • Systemic: methotrexate, ciclosporin, biologics (anti-TNF, IL-17, IL-23)

Drug therapy

  • Betamethasone 0.05% + calcipotriol gel daily
  • Methotrexate 7.5–25 mg weekly + folic acid

Complications

  • Psoriatic arthritis
  • Cardiometabolic disease
  • Erythroderma

Clinical pearls

  • Screen for PsA annually (PEST questionnaire)

Educational — verify locally.

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