Paracetamol Overdose

Toxicology

See treatment and investigations.

Management

  • Activated charcoal if <1 h and >150 mg/kg
  • Paracetamol level at 4 h post-ingestion
  • Plot on Rumack-Matthew nomogram (UK 100-line)
  • N-acetylcysteine: 21-h SNAP or 20.25 h regimen if above line, staggered ingestion, unknown time, or high risk
  • Refer for transplant assessment if King's College criteria met

Related in WardRound

Educational — verify locally.

WardRound

WardRound

Clinical Decisions in Seconds