CAP (CURB ≥2)
- Co-amoxiclav 1.2 g IV q8h + clarithromycin 500 mg q12h
- Severe: add levofloxacin or piperacillin-tazobactam
Neutropenic sepsis
- Piperacillin-tazobactam 4.5 g IV q6h
- Add vancomycin if line / MRSA risk
Meningitis
- Ceftriaxone 2 g IV q12h + dexamethasone 10 mg q6h
- Add amoxicillin 2 g q4h if >50 y or immunocompromised (Listeria)
Pyelonephritis
- Co-amoxiclav 1.2 g IV q8h or gentamicin 5 mg/kg + amoxicillin
- PO step-down: co-amoxiclav 625 mg TDS × 7–14 d
Cellulitis
- Flucloxacillin 1 g IV q6h
- Penicillin allergy: clindamycin 600 mg IV q8h
