GORD, peptic ulcer, gastroprotection, nausea/vomiting.
Regimens
GORD / dyspepsia
Omeprazole 20 mg PO OD × 4–8 weeks
H. pylori eradication
PPI BD + amoxicillin 1 g BD + clarithromycin 500 mg BD × 7 d
Acute UGIB (non-variceal)
Omeprazole 80 mg IV bolus then 8 mg/h infusion × 72 h post-endoscopy
Anti-emetics
Ondansetron 4–8 mg TDS (chemo, post-op); cyclizine 50 mg TDS (avoid HF); metoclopramide 10 mg TDS (avoid Parkinson's)
Monitoring
- • Symptom resolution
- • Mg²⁺ + B12 with long-term PPI
- • QTc with ondansetron + other QT drugs
Common prescribing errors
- ⚠ Long-term PPI without indication (review annually)
- ⚠ Metoclopramide in young women (dystonia)
- ⚠ Cyclizine in HF (fluid retention)
