Proteinuria >3.5 g/day + hypoalbuminaemia + oedema + hyperlipidaemia.
History taking
- • Onset, duration, progression, severity
- • Aggravating / relieving factors
- • Past history, drugs, allergies, comorbidities
- • Family & social history relevant to presentation
Examination
- • General: vitals, pallor, icterus, oedema, lymphadenopathy
- • Focused system examination
- • Look for red-flag findings
Red flags
- • Haemodynamic instability
- • Rapid deterioration
- • Severe pain or new neurological deficit
Differential diagnosis
- • See differentials section per chief complaint
Recommended investigations
- • 24-h urinary protein / ACR
- • Albumin, lipids, RFT, glucose
- • Immunology screen, viral hepatitis, HIV
- • Renal biopsy in adults
Diagnosis
- • Clinical diagnosis supported by targeted investigations
Initial treatment / management
- • Salt restriction, loop diuretic
- • ACEi/ARB
- • Statin
- • Anticoagulation if severe
Follow-up advice
- • Review in 2–4 weeks or earlier if worsening
- • Monitor response to therapy and adverse effects
Patient counselling
- • Explain diagnosis and natural course in lay terms
- • Red-flag symptoms warranting urgent return
- • Adherence to medications and follow-up
Referral criteria
- • Nephrology urgent
References
- • Harrison's Principles of Internal Medicine, 21e
- • NICE / WHO guidelines (current edition)
Educational outpatient guide — verify against local guidelines before clinical use.
