Lower Respiratory Tract Infection

General Medicine

Infection of the lower airways and lung parenchyma — acute bronchitis or community-acquired pneumonia (CAP).

History taking

  • • Cough (productive/dry), sputum colour, fever, pleuritic chest pain, dyspnoea
  • • Duration, prior antibiotics, vaccinations, occupational exposures
  • • Comorbidities: COPD, asthma, smoking, immunosuppression

Examination

  • • RR, SpO₂, temperature, BP, HR
  • • Chest: crackles, bronchial breath sounds, dullness, ↑ vocal fremitus
  • • Look for sepsis, dehydration, confusion (CURB-65)

Red flags

  • • RR ≥30, SpO₂ <92%, BP <90/60, confusion
  • • Multilobar involvement, pleural effusion, abscess on CXR
  • • Failure to respond after 48–72 h of appropriate therapy

Differential diagnosis

  • • Acute bronchitis (viral), COVID-19, influenza pneumonia
  • • Bacterial CAP (S. pneumoniae, H. influenzae, atypicals)
  • • TB, PE, pulmonary oedema, lung abscess, malignancy

Recommended investigations

  • • CBC, CRP/procalcitonin, electrolytes, RFT
  • • Chest X-ray; sputum Gram stain & culture, AFB
  • • Blood culture if febrile/severe; SARS-CoV-2 & influenza PCR
  • • ABG if SpO₂ <92%

Diagnosis

  • • CAP = new infiltrate + acute respiratory symptoms
  • • Severity: CURB-65 (Confusion, Urea>7, RR≥30, BP<90/60, Age≥65)

Initial treatment / management

  • • Outpatient (CURB-65 0–1): Oral amoxicillin or doxycycline; add macrolide if atypicals suspected
  • • Inpatient: IV beta-lactam + macrolide; ICU if severe
  • • Oxygen if SpO₂ <94%; bronchodilators if wheeze
  • • Vaccination: pneumococcal + influenza post-recovery

Prescription examples

  • • Tab Amoxicillin 1 g PO TDS x 5 d (CURB-65 0–1)
  • • Tab Doxycycline 100 mg PO BD x 5 d (penicillin allergy)
  • • Tab Azithromycin 500 mg PO OD x 3 d (atypical cover)
  • • Tab Paracetamol 650 mg PO TDS PRN

Follow-up advice

  • • Review at 48–72 h to assess response
  • • Repeat CXR at 6 weeks if smoker, >50 y, or persistent symptoms (exclude malignancy)

Patient counselling

  • • Smoking cessation, deep breathing exercises
  • • Pneumococcal & influenza vaccination
  • • Return immediately if breathlessness or confusion

Referral criteria

  • • CURB-65 ≥2, hypoxia, sepsis — admit
  • • Suspected TB, lung abscess, empyema, malignancy

Clinical pearls

  • • Procalcitonin can help reduce unnecessary antibiotic use
  • • Beware of post-influenza Staph. aureus pneumonia
  • • Always exclude TB in chronic cough with weight loss

References

  • • ATS/IDSA CAP Guidelines 2019
  • • BTS Guidelines for CAP in Adults 2009/2015 update

Educational outpatient guide — verify against local guidelines before clinical use.

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