Lower Respiratory Tract Infection

General Medicine

Infection of the lower airways and lung parenchyma — acute bronchitis or community-acquired pneumonia (CAP).

History taking

  • Cough (productive/dry), sputum colour, fever, pleuritic chest pain, dyspnoea
  • Duration, prior antibiotics, vaccinations, occupational exposures
  • Comorbidities: COPD, asthma, smoking, immunosuppression

Examination

  • RR, SpO₂, temperature, BP, HR
  • Chest: crackles, bronchial breath sounds, dullness, ↑ vocal fremitus
  • Look for sepsis, dehydration, confusion (CURB-65)

Red flags

  • RR ≥30, SpO₂ <92%, BP <90/60, confusion
  • Multilobar involvement, pleural effusion, abscess on CXR
  • Failure to respond after 48–72 h of appropriate therapy

Differential diagnosis

  • Acute bronchitis (viral), COVID-19, influenza pneumonia
  • Bacterial CAP (S. pneumoniae, H. influenzae, atypicals)
  • TB, PE, pulmonary oedema, lung abscess, malignancy

Recommended investigations

  • CBC, CRP/procalcitonin, electrolytes, RFT
  • Chest X-ray; sputum Gram stain & culture, AFB
  • Blood culture if febrile/severe; SARS-CoV-2 & influenza PCR
  • ABG if SpO₂ <92%

Diagnosis

  • CAP = new infiltrate + acute respiratory symptoms
  • Severity: CURB-65 (Confusion, Urea>7, RR≥30, BP<90/60, Age≥65)

Initial treatment / management

  • Outpatient (CURB-65 0–1): Oral amoxicillin or doxycycline; add macrolide if atypicals suspected
  • Inpatient: IV beta-lactam + macrolide; ICU if severe
  • Oxygen if SpO₂ <94%; bronchodilators if wheeze
  • Vaccination: pneumococcal + influenza post-recovery

Prescription examples

  • Tab Amoxicillin 1 g PO TDS x 5 d (CURB-65 0–1)
  • Tab Doxycycline 100 mg PO BD x 5 d (penicillin allergy)
  • Tab Azithromycin 500 mg PO OD x 3 d (atypical cover)
  • Tab Paracetamol 650 mg PO TDS PRN

Follow-up advice

  • Review at 48–72 h to assess response
  • Repeat CXR at 6 weeks if smoker, >50 y, or persistent symptoms (exclude malignancy)

Patient counselling

  • Smoking cessation, deep breathing exercises
  • Pneumococcal & influenza vaccination
  • Return immediately if breathlessness or confusion

Referral criteria

  • CURB-65 ≥2, hypoxia, sepsis — admit
  • Suspected TB, lung abscess, empyema, malignancy

Clinical pearls

  • Procalcitonin can help reduce unnecessary antibiotic use
  • Beware of post-influenza Staph. aureus pneumonia
  • Always exclude TB in chronic cough with weight loss

References

  • ATS/IDSA CAP Guidelines 2019
  • BTS Guidelines for CAP in Adults 2009/2015 update

Educational outpatient guide — verify against local guidelines before clinical use.

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