Prolonged PT + aPTT
Common causes
- • Liver disease
- • DIC
- • Warfarin overdose
- • Vit K deficiency
- • Massive transfusion
Significance: Mixing study differentiates factor deficiency from inhibitor.
Differential diagnosis
- • DIC
- • Liver failure
- • Anticoagulant overdose
Next investigations
- • Mixing study
- • Fibrinogen
- • D-dimer
- • Factor assays
Red flags
- • INR >5 with bleeding
- • DIC with end-organ damage
