Neurology · Broad-spectrum antiseizure
Sodium Valproate
Dose
Adults 600 mg/day in 2 doses; increase by 200 mg q3 days (usual 1000–2000 mg/day). IV load 20–40 mg/kg in status.
Use
Generalised epilepsy, absence, myoclonic seizures, bipolar disorder.
Monitoring
LFTs (first 6 months), FBC, ammonia if encephalopathic, valproate level if compliance in doubt.
Side effects
- • Weight gain
- • Tremor
- • Hair loss
- • Hepatotoxicity
- • Hyperammonaemic encephalopathy
- • Pancreatitis
Pregnancy safety
Contraindicated in women of childbearing potential unless pregnancy-prevention programme in place.
Related in WardRound
Hyperkalaemia
Protocol · K⁺ > 5.5 mmol/L
Tricyclic Antidepressant Overdose
Protocol · QRS widening = give bicarbonate
Salicylate Poisoning
Protocol · Alkaline diuresis + dialysis
Cyanide Poisoning
Protocol · Hydroxocobalamin
Methanol / Ethylene Glycol Poisoning
Protocol · Fomepizole + dialysis
Aluminium Phosphide Poisoning
Protocol · Coconut oil + supportive
Epilepsy
Topic · Neurology
TCA Overdose
Topic · Toxicology
Always confirm dose against your local formulary / BNF before prescribing.
