Respiratory · PDE4 inhibitor
Roflumilast
Dose
250 mcg OD × 4 weeks then 500 mcg OD.
Use
Severe COPD with chronic bronchitis and frequent exacerbations (FEV₁ <50%).
Monitoring
Weight (loss common), mood, GI tolerance.
Side effects
- • Weight loss
- • Diarrhoea
- • Nausea
- • Depression/suicidality
Always confirm dose against your local formulary / BNF before prescribing.
