ICU Drugs · Non-depolarising neuromuscular blocker
Rocuronium
Dose
RSI 1.0–1.2 mg/kg IV; maintenance 0.15 mg/kg PRN or 5–10 mcg/kg/min infusion
Mechanism
Competitive nicotinic acetylcholine receptor antagonist at NMJ
Indications
- • RSI
- • Facilitate mechanical ventilation
- • Surgical paralysis
Contraindications
- • Known hypersensitivity
Use
Rapid-onset (~60 s) non-depolarising agent; sugammadex reversal.
Monitoring
Train-of-four (TOF), ventilation, awareness (always pair with sedation).
Side effects
- • Anaphylaxis
- • Prolonged paralysis in hepatic / renal disease
Pregnancy safety
Safe in caesarean RSI
Related in WardRound
Always confirm dose against your local formulary / BNF before prescribing.
