Endocrinology · Thiazolidinedione (PPAR-γ agonist)
Pioglitazone
Dose
15–30 mg OD; max 45 mg OD.
Contraindications
- • Heart failure
- • Active bladder cancer
- • Macroscopic haematuria under investigation
Use
Insulin resistance in T2DM; benefit in NASH and post-stroke insulin resistance.
Monitoring
Weight, oedema, LFTs, bone density in older women.
Side effects
- • Fluid retention / heart failure
- • Weight gain
- • Fractures
- • Bladder cancer signal
Related in WardRound
Always confirm dose against your local formulary / BNF before prescribing.
