Psychiatry · Atypical antipsychotic
Olanzapine
Dose
5–10 mg PO OD (max 20 mg); 5–10 mg IM for acute agitation, max 3 doses/24 h.
Contraindications
- • Do not give IM olanzapine within 1 h of IM benzodiazepine (cardiorespiratory depression)
Use
Schizophrenia, bipolar mania, acute agitation, chemotherapy-induced nausea.
Monitoring
Weight, waist, HbA1c, lipids at baseline/3 months/annually; prolactin; ECG.
Side effects
- • Metabolic syndrome, weight gain
- • Sedation
- • Postural hypotension
- • Extrapyramidal effects (less than typicals)
Related in WardRound
Always confirm dose against your local formulary / BNF before prescribing.
