N-Acetylcysteine

Emergency Drugs

Emergency Drugs

N-Acetylcysteine

Dose

21-h regimen: 150 mg/kg in 200 mL over 1 h, then 50 mg/kg in 500 mL over 4 h, then 100 mg/kg in 1 L over 16 h

Use

Paracetamol overdose (use nomogram).

Monitoring

LFTs, INR, U&E.

Side effects

  • Anaphylactoid reaction (rate-related)
  • Nausea
  • Flushing

Always confirm dose against your local formulary / BNF before prescribing.

WardRound

WardRound

Clinical Decisions in Seconds