Cardiology · Angiotensin receptor blocker (ARB)
Losartan
Dose
50–100 mg OD.
Mechanism
Blocks AT1 receptor — no bradykinin accumulation → no cough.
Indications
- • HTN
- • HFrEF (if ACEi intolerant)
- • Diabetic nephropathy (RENAAL)
- • Uric acid–lowering effect
Contraindications
- • Pregnancy
- • Bilateral RAS
- • Concomitant ACEi + aliskiren in diabetes
Dose adjustment
Hepatic impairment: start 25 mg
Use
Alternative to ACEi when cough or angio-oedema.
Monitoring
U&E, BP, K+.
Side effects
- • Hyperkalaemia
- • Renal impairment
- • Hypotension
Pregnancy safety
Contraindicated.
Always confirm dose against your local formulary / BNF before prescribing.
