Cardiology · ACE inhibitor (not a prodrug)
Lisinopril
Dose
2.5–40 mg OD.
Mechanism
Direct ACE inhibition, renal excretion.
Indications
- • Hypertension
- • HFrEF
- • Post-MI (GISSI-3)
Contraindications
- • Pregnancy
- • Bilateral RAS
- • Angio-oedema history
Dose adjustment
CrCl <30: start 2.5 mg
Use
Once-daily ACEi with no hepatic metabolism.
Monitoring
U&E, BP.
Side effects
- • Cough
- • Hyperkalaemia
- • Hypotension
Always confirm dose against your local formulary / BNF before prescribing.
