Neurology · Dopamine precursor + DDC inhibitor
Levodopa/Carbidopa
Dose
100/25 mg PO TDS initially; titrate weekly to response (max ~2000 mg levodopa/day).
Mechanism
Levodopa crosses BBB and is decarboxylated to dopamine; carbidopa blocks peripheral conversion.
Indications
- • Parkinson's disease
- • Dopa-responsive dystonia
Contraindications
- • Narrow-angle glaucoma
- • Concurrent non-selective MAOI
Use
Most effective symptomatic therapy for bradykinesia and rigidity.
Monitoring
Motor fluctuations, dyskinesia, postural BP, impulse-control behaviours.
Side effects
- • Nausea
- • Orthostatic hypotension
- • Dyskinesia, wearing-off
- • Hallucinations in elderly
Related in WardRound
Always confirm dose against your local formulary / BNF before prescribing.
