Neurology · Sodium-channel blocker
Lamotrigine
Dose
25 mg OD × 2 wk → 50 mg OD × 2 wk → increase 50–100 mg q1–2 wk (usual 100–400 mg/day). Halve dose with valproate.
Use
Focal and generalised epilepsy; bipolar depression maintenance. Preferred antiseizure drug in pregnancy.
Monitoring
Rash (stop immediately), seizure frequency; levels fall in pregnancy — recheck each trimester.
Side effects
- • Rash / Stevens-Johnson syndrome
- • Headache
- • Diplopia
- • Insomnia
Related in WardRound
Always confirm dose against your local formulary / BNF before prescribing.
