Cardiology · ACE inhibitor (prodrug)
Enalapril
Dose
PO 2.5 mg BD → 10–20 mg BD. IV enalaprilat 0.625–1.25 mg q6h.
Mechanism
Converted to enalaprilat → ACE inhibition.
Indications
- • HFrEF
- • Hypertension
- • Diabetic nephropathy
Contraindications
- • Pregnancy
- • Bilateral RAS
- • Prior angio-oedema
Dose adjustment
CrCl <30: halve dose
Use
Alternative ACEi (SOLVD, CONSENSUS trials).
Monitoring
U&E, BP, K+.
Side effects
- • Cough
- • Hypotension
- • Hyperkalaemia
Always confirm dose against your local formulary / BNF before prescribing.
