Cardiology · Thiazide-like diuretic
Chlorthalidone
Dose
12.5–25 mg PO OD.
Mechanism
NCC inhibition in distal tubule; long half-life.
Indications
- • Hypertension (ALLHAT, SPRINT)
- • Nephrogenic DI
Use
Preferred thiazide-like agent (longer duration than HCTZ).
Monitoring
U&E, glucose, lipids, urate.
Side effects
- • Hypokalaemia
- • Hyponatraemia
- • Hyperuricaemia
- • Impotence
Always confirm dose against your local formulary / BNF before prescribing.
