Antibiotics · Polyene antifungal
Liposomal Amphotericin B
Dose
3–5 mg/kg IV OD (up to 10 mg/kg in mucormycosis); infuse over 30–60 min.
Use
Invasive mould infection, cryptococcal meningitis induction, visceral leishmaniasis.
Monitoring
Daily U&E, magnesium and potassium (replace aggressively), creatinine, FBC.
Side effects
- • Nephrotoxicity
- • Hypokalaemia, hypomagnesaemia
- • Infusion reactions
- • Anaemia
Always confirm dose against your local formulary / BNF before prescribing.
