Red flags
- Core temp >40 °C + CNS dysfunction
- Multiorgan failure
- DIC, rhabdomyolysis
First steps
- ABCDE + rapid cooling (ice-water immersion preferred, or evaporative)
- IV fluids
- Monitor core temp continuously
Key investigations
- CK, U&E, LFT, coag, glucose, ABG
- Urinalysis
Differentials
- Sepsis, malignant hyperthermia, NMS, serotonin syndrome
Initial management
- Stop cooling at 39 °C
- Treat rhabdomyolysis (fluids)
- AVOID antipyretics (ineffective, hepatotoxic)
- ICU admit for organ support
Referral
- ICU
AI clinical assessment
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This tool is for educational and clinical support only. It does not replace professional medical judgment or institutional protocols.
