Severe/Life-Threatening Asthma

O₂, SABA, ipratropium, steroids, Mg

Red flags
  • Silent chest, cyanosis, exhaustion
  • SpO₂ <92%, normal or ↑ PaCO₂
  • Altered consciousness

First steps

  • ABCDE + O₂ to SpO₂ 94-98%
  • Nebulised salbutamol 5 mg + ipratropium 500 mcg back-to-back
  • Prednisolone 40-50 mg PO or hydrocortisone 100 mg IV
  • IV access

Key investigations

  • Peak flow (compare with best/predicted)
  • SpO₂, ABG if not improving
  • CXR to exclude pneumothorax

Differentials

  • COPD exacerbation
  • Anaphylaxis
  • Pneumonia
  • PE
  • Cardiac wheeze

Initial management

  • Magnesium sulfate 2 g IV over 20 min if severe/life-threatening
  • IV salbutamol/aminophylline (specialist)
  • NIV/intubation if exhausted, silent chest, or rising CO2
  • Admit to HDU/ICU

Referral

  • Respiratory / ICU
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