Common organisms
- • Strep pyogenes
- • Staph aureus (incl. MRSA)
Empirical therapy
- • Mild: Flucloxacillin 500 mg-1 g PO QDS
- • Severe: Cefazolin / Flucloxacillin IV
- • Add Vancomycin if MRSA risk
Culture-directed
- • Per culture; MSSA: Flucloxacillin
Adverse effects
- • Allergy
- • Hepatitis with flucloxacillin
Monitoring
- • Mark border
- • Look for necrotising features
Clinical pearls
- • Pain disproportionate, crepitus, bullae → urgent surgical review for necrotising fasciitis
Educational support only — follow local antibiogram and institutional protocols.
