Common organisms
- • Broad — depends on source
Empirical therapy
- • Piperacillin-tazobactam 4.5 g IV q8h
- • Add Vancomycin if MRSA risk
- • Add antifungal if neutropenic / line sepsis
Culture-directed
- • Narrow within 48h based on cultures
Adverse effects
- • Multidrug toxicity
- • C. difficile
Monitoring
- • Lactate clearance, MAP ≥65
- • Daily review of source and de-escalation
Clinical pearls
- • Antibiotics within 1h of recognition
- • Take 2 sets of blood cultures before antibiotics
Educational support only — follow local antibiogram and institutional protocols.
