Common organisms
- • Gram-negatives incl. Pseudomonas
- • Gram-positives from lines
- • Fungi if prolonged
Empirical therapy
- • Piperacillin-tazobactam 4.5 g IV q8h within 1h
- • Add Vancomycin if line sepsis / shock / MRSA risk
Culture-directed
- • Per cultures; antifungal (Caspofungin) if fever persists >96h
Adverse effects
- • Multiple drug interactions
Monitoring
- • Daily review, source identification
- • Repeat blood cultures if persistent fever
Clinical pearls
- • Door to antibiotic <60 min
- • Do not delay for line removal
Educational support only — follow local antibiogram and institutional protocols.
